Prophylactic and Antidiabetic Effect of Andrographis paniculata and its Combination with Allium sativum on Blood Glucose Level and some Biochemical Indices in Wistar Rats

Diabetes Mellitus is a chronic health problem with devastating effect that characterized by high blood glucose levels resulting from faults or flaws in insulin production action. The unaffordability and adverse effects of conventional drugs the treatment management many diseases has spurred interest scientists to use herbal medicine treat manage ailments. purpose this study was investigate prophylactic anti-diabetic Andrographis paniculata its combination Allium sativum on level some biochemical indices wistar rats. bodyweight, fasting level, lipid profile peroxidation were determined using standard methods. All groups indicated gradual increase their body weights which not above normal control significant reduction also observed all but far greater seen pretreated percentage 61.25%. result showed varying doses A. significantly reduced LDL, TCHOL, TRIG VLDL diabetic However, pretreatment gave higher levels. MDA test decreased when compared untreated group drug (p< 0.05) treated 100mg/kg 200mg/kg paniculata. findings research potential be used as remedy for diabetes mellitus complications, however highly recommended it gives better results reducing complications associated mellitus.